A Brief Description
We recently developed a deep learning method that enabled us to identify 88 nucleosome positioning features. This website takes a nucleosome occupancy profile as input and, after smoothing the profile, centers a 20-base window at each local maximum, provided that these maxima do not overlap with other maxima located within 160 bases of each other. Each position within the window is considered a potential dyad position and is scored based on the 88 identified features. The genomic coordinate with the highest score is selected as the dyad position. In addition, the website provides a classifier for nucleosomal and non-nucleosomal DNA and generates a nucleosome positioning score accordingly. NUCLEONE is freely accessible to both academic and commercial users.
